GeneAb™

BRAF V600E

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$210.00

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Cat. No.

IHC600-100

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Description

Serine/threonine-protein kinase B-Raf (BRAF) is a cytoplasmic serine-threonine kinase of the RAF family which mediates downstream cellular responses to growth signals through the mitogen-activated protein kinase (MAPK) signaling pathway. Oncogenic mutations in the BRAF gene, 80% of which are a single V600E substitution within the kinase domain, constitutively activate the MAPK signaling pathway and result in increased cell proliferation and apoptosis resistance. The V600E mutation is observed in colorectal cancer, non-Hodgkin lymphoma, papillary thyroid carcinoma, malignant melanoma, non-small-cell lung carcinoma, and lung adenocarcinoma. BRAF V600E is therefore an important immunohistochemical marker for tumor diagnosis and prognosis.

Specifications

Clone IHC600
Source Mouse Monoclonal
Positive Control Colorectal Adenocarcinoma, Thyroid Papillary Carcinoma with the BRAF V600E Mutation
Dilution Range 1:100 - 1:200

References

  1. Li WQ, et al. Mol Cancer. 2006; 5:2
  2. Davies H, et al. Nature. 2002; 417:949-954.
  3. Benlloch S, et al. J Mol Diagn. 2006; 8: 540–3.
  4. Gear H, et al. Invest Ophthalmol Vis Sci. 2006; 45:2484–8.
  5. Capper D, et al. Acta Neuropathol. 2011; 122:11-19.