GeneAb™

Beta-Catenin

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Cat. No.

IHC516-100

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Description

Beta-Catenin is a cytoplasmic protein with a dual role in cell-cell adhesion and gene expression. It is normally present in the submembranous regions of the cell. Nuclear accumulation of beta-catenin has been found to occur as a result of gene mutations. This accumulation is useful in identifying desmoids tumours (fibromatosis) in the abdomen and breast, and is therefore useful in differentiating other cell neoplasms in these regions.

Specifications

Clone IHC516
Source Mouse Monoclonal
Positive Control Fibromatosis Of Breast
Dilution Range 1:100 - 1:200

References

  1. Abraham S, et al. Hum Pathol. 2002; 33:39-46.
  2. Montgomery E, et al. Am J Surg Pathol. 2002; 26:1296-1301