GeneAb™

Beta-Catenin

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IHC516-100

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Description

Beta-Catenin is a cytoplasmic protein with a dual role in cell-cell adhesion and gene expression. It is normally present in the submembranous regions of the cell. Nuclear accumulation of beta-catenin has been found to occur as a result of gene mutations. This accumulation is useful in identifying desmoids tumours (fibromatosis) in the abdomen and breast, and is therefore useful in differentiating other cell neoplasms in these regions.
  • References
    1. Abraham S, et al. Hum Pathol. 2002; 33:39-46.
    2. Montgomery E, et al. Am J Surg Pathol. 2002; 26:1296-1301

Specifications

Clone IHC516
Source Mouse Monoclonal
Positive Control Fibromatosis Of Breast
Dilution Range 1:50-1:200

Literature