GeneAb™

CD117/c-kit

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$145.00

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Cat. No.

IHC526-100

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Description

CD117 or Proto-oncogene c-Kit (c-Kit) is a member of the Tyrosine Kinase Receptor (TKR) family which is an important cell surface marker found on hematopoietic stem cells, melanocytes, mast cells, Cajal cells, germ cells, basal cells of skin, and mammary ductal epithelia. It is considered an important marker in the diagnosis and classification of Gastrointestinal Stromal Tumors (GISTs), mast cell diseases, Acute Myeloid Leukemia (AML), Small Cell Lung Carcinoma (SCLC), and Ewing's sarcoma.

Specifications

Clone IHC526
Source Mouse Monoclonal
Positive Control Gastrointestinal Stromal Tumor, Seminoma
Dilution Range 1:100 - 1:200

References

  1. Yarden Y, et al. EMBO J. 1987; 6:3341-51.
  2. Edling CE, et al. Int J Biochem Cell Biol. 2007; 39:1995–8.
  3. Turner MS, et al. Arch Pathol Lab Med. 2009; 133:1370-4.
  4. Tsuura Y, et al. Virchows Arch. 1994; 424:135-41.
  5. Smithey BE, et al. Am J Surg Pathol. 2002; 26:486-92.
  6. Natkunam Y, et al. Am J Surg Pathol. 2000; 24:81-91.