Cluster of Differentiation 123 (CD123), also known as Interleukin-3 Receptor, plays an important role in regulating the immune system by transmitting interleukin-3 signals, thereby promoting proliferation and differentiation of hematopoietic stem cells. Studies suggest that the expression of CD123 is observed in most Acute Myeloid Leukemia (AML) subtypes, including leukemic stem cells. CD123 positive AML has demonstrated higher marrow blast percentages and monocytic differentiation, and clinical presentations for AML mostly include bone marrow involvement and regional lymphadenopathy. As there are overlapping clinical presentations between AML and blastic NK-cell lymphomas, differential diagnosis is important; use of a panel of CD123, CD4, CD56, and TCL-1 can help with this distinguishment between AML and myeloid involvement from blastic NK-cell lymphomas.

• CD123 Datasheet IVDR
• CD123 Datasheet IVDR

• MSDS

CLONE:
IHC123

ISOTYPE:


HOST SPECIES:
Mouse

CLONALITY:
Monoclonal

POSITIVE CONTROL:
Tonsil

DILUTION RANGE:


INTENDED USE/REG. STATUS:
IVDR