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Cluster of differentiation 123 (CD123), also known as interleukin-3 receptor, is normally expressed on pluripotent progenitor cells. It plays an important role in regulating the immune system by transmitting interleukin-3 signals, thereby promoting proliferation and differentiation of hematopoietic stem cells into myeloid or lymphoid progenitor cells. Samples obtained from intermediate risk groups suggest that the expression of CD123 is observed in most Acute Myeloid Leukemia (AML) subtypes, including leukemic stem cells. CD123 positive AML has demonstrated higher marrow blast percentages and monocytic differentiation, and clinical presentations for AML mostly include bone marrow involvement and regional lymphadenopathy. As there are overlapping clinical presentations between AML and blastic NK-cell lymphomas, differentiatial diagnosis is important; use of an IHC panel that includes antibodies against CD123, CD4, CD56, and TCL-1 can help with this distinguishment between AML and myeloid involvement from blastic NK-cell lymphomas.
  • References
    1. Cronin D, et al. Am J Clin Pathol. 2012; 137:367-76.
    2. Rollins-Raval M, et al. Appl Immunohistochem Mol Morphol. 2013; 21:212-7.


Clone IHC123
Source Mouse Monoclonal
Positive Control Blastic Plasmacytoid, Dendritic Cell Neoplasm
Dilution Range 1:50-1:200