GeneAb^TM CD2 [IHC531] on Tonsil

Reference Panels

Breast/Gynecological Pathology

Dermatopathology

Gastrointestinal (GI) Pathology

Genitourinary (GU) Pathology

Head and Neck Pathology

Hematopathology

Neuropathology

Pediatric Pathology

Pulmonary Pathology

Soft Tissue Pathology

Cytopathology

GeneAb™

Description

Cluster of differentiation 2 (CD2) is a useful early T-cell lineage restricted antigen that is present in T-cell differentiation. As a pan-T-cell marker, CD2 staining is used for recognizing practically all normal T-cells, but may be deleted in some T-cell neoplasms. Since CD2 is present in most precursor and mature T-cell leukemias and lymphomas, it is useful in the evaluation of lymphoid malignancies. By using CD2 and CD25 staining, the recognition of systemic mastocytosis and mastocytic leukemia is supported.

• References

  1. Went P, et al. J Clin Oncol. 2006; 24:2472-2479.
  2. Aguilera NS, et al. Arch Pathol Lab Med. 2006; 130:1772-9.
  3. Barrionuevo C, et al. Appl Immunohistochem Mol Morphol. 2007; 15:38-44.
  4. Bovenschen HJ, et al. Br J Dermatol. 2005; 153:72-8.
  5. Foon KA, et al. Blood 1986; 68:1- 31.

Specifications

Literature