GeneAb™

CD23

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Cat. No.

IHC023-100

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Description

Cluster of differentiation 23 (CD23) is found on interleukin-4 activated B cells, activated macrophages, eosinophils, and follicular dendritic cells, and is a receptor for IgE, an antibody involved in parasitic immunity. CD23 is present on Reed-Sternberg cells in Hodgkin’s disease. Follicular dendritic cells and activated B-lymphocytes produce strong staining in germinal centers and weak patterns in mantle zone B-cells. CD23 is helpful in differentiating chronic lymphocytic leukemia from mantle cell leukemia. Small B-cell lymphomas are sometimes positive, while precursor B- and T-lymphomas, myeloid neoplasms, and mature T-cell lymphomas stain negatively with Anti-CD23.

Specifications

Clone IHC023
Source Mouse Monoclonal
Positive Control Tonsil, Lymph Node, Cll/Sll
Dilution Range 1:100 - 1:200

References

  1. Lichtman AH, et al. Philadelphia: Saunders. 2003; 324–325. ISBN 0-7216-0008-5.
  2. Henningsson F, et al. PLoS One. 2011; 6:e21760.
  3. Barna G, et al. Hematol Oncol. 2008; 26:167–70.
  4. Kurtin PJ, et al. Am J Clin Pathol. 1999; 112:319-29.
  5. Cooper K. London: Greenwich Medical Media. 2003; 95. ISBN 1-84110-100-1.