GeneAb™

CD25

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$140.00

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Cat. No.

IHC025-100

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Description

Cluster of differentiation 25 (CD25) is the extracellular region of the interleukin-2 receptor on activated B- and T-cells, myeloid precursors, and some other types of leukocytes. Since CD25 staining is useful for differentiating neoplastic mast cell aggregates from reactive proliferations, Anti-CD25 has become a major criterion for Systemic Mastocytosis diagnoses. In the context of urticaria pigmentosa, CD25 staining is also used to recognize mast cells in skin biopsies. There is a greater proportion of CD25+ and FOXP3+ regulatory T cells among cancer cells in tumor parenchyma and its periphery in recurrent cutaneous melanoma compared to non-recurrent melanoma.

Specifications

Clone IHC025
Source Mouse Monoclonal
Positive Control Lesions Of Mastocytosis
Dilution Range 1:100 - 1:200

References

  1. Triplett T, et al. Eur J Immunol. 2012; 42:1893-1905.
  2. Hahn H, et al. Am J Surg Pathol. 2011; 31:1669-76.
  3. Hollmann TJ, et al. Am J Surg Pathol. 2008; 32:139-45.
  4. Miracco C, et al. Oncol Rep. 2007; 18:1115-22.
  5. Siddiqui SA, et al. Clin Cancer Res. 2007; 13:2075-81.