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Cluster of differentiation 38 (CD38) is an ontogenesis marker in T-cells, which is present at low to moderate levels on several hematopoietic cells and in some solid tissues. CD38(+) stained B-cells are mainly present in germinal centers of secondary lymphoid organs, while the marginal zone is usually negative. Circulating monocytes are CD38 positive, while residential macrophages are CD38 negative. CD38 is also expressed in erythrocytes, platelets, prostate epithelial cells, islet cells, smooth and striated muscle cells, renal tubules, and retinal ganglial cells. CD38 in a panel with CD138, MUM1 and EMA is very useful for the diagnosis of immunodeficiency-related lymphoma, such as plasmablastic lymphoma, primary effusion lymphoma, and large B-cell lymphoma in Castleman disease. Current research found a panel of CD38, CD44, and TCL-1 staining to be useful in recognizing large B-cell lymphoma with c-Myc gene rearrangement thus is important in differential diagnoses of diffuse large B-cell lymphoma, Burkitt lymphoma, and B-cell lymphoma.
  • References
    1. Martin F, et al. Nat Rev Immunol. 2002; 2:323-35.
    2. Dono M, et al. J Immunol. 2000; 164:5596-5604.
    3. Malavasi F, et al. Physiol Rev. 2008; 88:841-86.
    4. Dave SS, et al. N Engl J Med. 2006; 354:2431–42.
    5. Leoncini L, et al. IARC WHO Press Lyon France. 2008; 262-4.
    6. Rodig S, et al. Am J Surg Pathol. 2008; 32:113–122.
    7. Naresh KN, et al. Br J Haematol. 2011; 154:770–6.


Clone IHC038
Source Mouse Monoclonal
Positive Control Plasma Cell Myeloma, Plasma Cells, Lymph Node, Bone Marrow
Dilution Range 1:50-1:200