GeneAb™

CD45R

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Cat. No.

IHC536-100

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Description

CD45R, also known as MB1, is an isoform of CD45 that is a member of the protein tyrosine phosphatase (PTPase) family. CD45R is expressed specifically on the surface of hematopoietic cells, and has demonstrated function as a regulator of the antigen and cytokine receptor signalling of B and T cells. Given that the antigen is located in the membrane of all B cells, with the exception of plasma cells and some mature T cells, Anti-CD45R exhibits specific reactivity with most B lymphocytes. The use of Anti-CD45R is primarily useful in distinguishing B cell lymphomas from T cell lymphomas, with specific reactivity to follicle center cells, mantle cells, some medullary thymocytes, and 80% of B cell lymphomas.
  • References
    1. Myskow M, et al. Am J Clin Pathol. 1988; 90:564-74.
    2. Shin S, et al. Hum Pathol. 1992; 23:686-94.

Specifications

Clone IHC536
Source Mouse Monoclonal
Positive Control Lymph Node, Tonsil
Dilution Range 1:50-1:200

Literature