GeneAb™

CD56

(Coming soon)

Select Format:

Select Volume:

Price:

$120.00

Quantity:

Cat. No.

IHC056-100

Inquire

Description

Cluster of differentiation 56 (CD56), also known as Neural-Cell Adhesion Molecule (NCAM), is a glycoprotein involved in synaptic plasticity, cell-cell adhesion, neurite outgrowth, learning, and memory. NCAM is expressed in normal neurons, glia, natural killer cells, activated T-cells, brain and cerebellum, neuroendocrine tissues, and skeletal muscle. Anti-CD56 recognizes a number of tumors including myeloma, myeloid leukemia, natural killer/T-cell lymphomas, neuroendocrine tumors, pancreatic acinar-cell carcinoma, pheochromocytoma, and Wilm’s tumor. CD56 is detectable in neoplasms that are neuroectodermally-derived, such as retinoblastoma, medulloblastomas, astrocytomas, small cell carcinomas, and neuroblastomas. It has also been linked to rhabdomyosarcoma, a tumor that is mesodermally-derived.

Specifications

Clone IHC056
Source Mouse Monoclonal
Positive Control Neuroblastoma
Dilution Range 1:100 - 1:200

References

  1. Gattenlöhner S, et al. Am J Pathol. 2009; 174:1160-71.
  2. Marafioti T, et al. Blood. 2008; 111:3778-92.
  3. Chang CC, et al. Am J Clin Pathol. 2000; 114:807-11.
  4. Savoia P, et al. Br J Dermatol. 1997; 137:966-71.
  5. Natkunam Y, et al. J Cutan Pathol. 2000; 27:392-9.
  6. Gerardy-Schahn R, et al. Int J Cancer Sup. 1994; 8:38-42.
  7. Michalides R, et al. Int J Cancer Sup. 1994; 8:34-7.
  8. Kibbelaar RE, et al. Eur J Cancer. 1991; 27:431-5.
  9. Moolenaar CE, et al. Cancer Res. 1990; 50:1102-6.
  10. Langdon SP, et al. Cancer Res. 1988; 48:6161-5.
  11. Sumi M, et al. Leuk Lymphoma. 2003; 44:201-4.
  12. Trejo O, et al. J Cutan Pathol. 2002; 29:397-406.
  13. Ely SA, et al. Am J Pathol. 2002; 160:1293-9.
  14. Tao J, et al. Am J Surg Pathol. 2002; 26:111-8.
  15. Kaufmann O, et al. Hum Pathol. 1997; 28:1373-8.