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Cluster of differentiation 68 (CD68) is a heavily glycosylated transmembrane antigen that is detected in lysosomes, tissue macrophages, Langerhans cells, dendritic cells, monocytes, Kupffer cells, osteoclasts, and granulocytes. Anti-CD68 may be useful in identifying myelomonocytic and histiocytic tumors, and for differentiating between malignant fibrous histiocytoma and other pleomorphic sarcomas. However, other lysosome-rich cells may also stain, since Anti-CD68 detects a formalin-resistant epitope that may be associated with lysosomal granules.
  • References
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    7. Snow JL, et al. Br J Dermatol. 1995; 133:71-6.
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    12. Kunz-Schughart LA, et al. Verh Dtsch Ges Pathol. 2003; 87:215-23.
    13. Horny HP, et al. Hum Pathol. 1994; 25:810-4.


Clone IHC068
Source Mouse Monoclonal
Positive Control Tonsil
Dilution Range 1:50-1:200