GeneAb™

CD7

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$165.00

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Cat. No.

IHC541-100

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Description

Cluster of differentiation 7 (CD7) is an antigen expressed in immature and mature T-lymphocytes, thymocytes, peripheral blood T-cells, natural killer cells, myeloid precursors, fetal liver and bone marrow, a small subpopulation of normal B-cells, and malignant B-cells. The antigen belongs to the immunoglobulin gene superfamily, and plays an important role in T-cell interactions and T-cell/B-cell interactions during early lymphoid development. CD7 is indicated as a marker for acute myelogenous leukemia and chronic myelogenous leukemia, and for neoplastic proliferations such as T-cell acute lymphoblastic leukemia/lymphoma. Anti-CD7, when used in adjunct with Anti-CD4, is useful for differentiating mycosis fungoides or Sézary syndrome (both cutaneous T-cell lymphomas) from benign dermatoses.

Specifications

Clone IHC541
Source Mouse Monoclonal
Positive Control Tonsil, Peripheral T-Cell Lymphoma
Dilution Range 1:100 - 1:200

References

  1. Hodak E, et al. J Am Acad Dermatol. 2006; 55:276-84.
  2. Went P, et al. J Clin Oncol. 2006; 24:2472-9.