GeneAb™

CD74

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$135.00

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Cat. No.

IHC074-100

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Description

Cluster of differentiation 74 (CD74), also known as the MHC Class II-associated invariant chain (II), is a transmembrane protein expressed mainly by epithelial cells and antigen-presenting cells such as B-lymphocytes, macrophages, and monocytes. Anti-CD74 is used in distinguishing atypical fibroxanthoma from malignant fibrous histiocytoma, and Small Cell Lung Carcinoma (SCLC) from Non-Small Cell Lung Carcinoma (NSCLC). CD74 is clinically indicated as a marker for germinal center lymphocytes and B-cell lymphomas.

Specifications

Clone IHC074
Source Mouse Monoclonal
Positive Control Tonsil, Lymph Node
Dilution Range 1:100 - 1:200

References

  1. Supernat A, et al. Appl Immunohistochem Mol Morphol. 2012; 20:103-7.
  2. Zhang B. Cancer Res. 2010; 70:6407-11.
  3. Antonioli L, et al. Trends Cancer. 2016; 2:95-109.
  4. Gao ZW, et al. Biomed Res Int. 2014; 2014:460654.