GeneAb^TM CDX-2 [IHC402] on Duodenum

Reference Panels

Breast/Gynecological Pathology

Dermatopathology

Gastrointestinal (GI) Pathology

Genitourinary (GU) Pathology

Head and Neck Pathology

Hematopathology

Neuropathology

Pediatric Pathology

Pulmonary Pathology

Soft Tissue Pathology

Cytopathology

GeneAb™

Description

CDX-2 is a caudal-related homeobox transcription factor that is expressed by intestinal epithelial cells. CDX-2 is a useful marker for gastrointestinal carcinoma, and for determining the origin of gastrointestinal metastatic adenocarcinoma and carcinoids. Anti-CDX-2 is used for differentiating lung and metastatic colorectal adenocarcinoma, however mucinous ovarian carcinoma also react positively with Anti-CDX-2, thereby limiting the ability to differentiate from metastatic colorectal adenocarcinoma.

• References

  1. Suh E, et al. Mol Cell Biol. 1994; 14:7340-51.
  2. Liu Q, et al. Mod Pathol. 2007; 20:1286–97.
  3. Mazziotta RM, et al. Appl Immunohistochem Mol Morphol. 2005; 13:55-60.
  4. Erickson LA, et al. Endocr Pathol. 2004; 15:247-5.
  5. Kaimaktchiev V, et al. Mod Pathol. 2004; 17:1392-9.
  6. Werling RW, et al. Am J Surg Pathol. 2003; 27:303-10.
  7. Scholl C, et al. J Clin Invest. 2007; 117:1037–48.

Specifications

Literature