GeneAb™

CTLA-4

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$210.00

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Cat. No.

IHC004-100

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Description

Cytotoxic T-lymphocyte-associated protein 4 (CTLA-4) is a receptor on T Helper cells that functions as an immune checkpoint and downregulator of immune responses. Mutations in CTLA-4 are associated with insulin-dependent diabetes mellitus, Hashimoto’s thyroiditis, Graves’ disease, systemic lupus erythematosus (SLE), celiac disease, primary biliary cirrhosis, thyroid-associated orbitopathy, multiple sclerosis, and other autoimmune diseases. The spliced variant of CTLA-4 in SLE is present in the patient’s serum. Haploinsufficiency of CTLA-4 causes the immune system disorder known as CTLA-4 deficiency or CHAI disease (CTLA4 haploinsufficiency with autoimmune infiltration).

Specifications

Clone IHC004
Source Mouse Monoclonal
Positive Control Tonsil, Lymph Node, Colon, Thymus
Dilution Range 1:100 - 1:200

References

  1. Denizot F, et al. Nature. 1987; 328:267–70.
  2. Dariavach P, et al. Eur J Immunol. 1988; 18:1901–5.
  3. Krummel MF, et al. J Exp Med. 1995; 182:459–65.
  4. Kuehn HS, et al. Science. 2014; 345:1623–7.
  5. Walunas TL, et al. J Exp Med. 1996; 183:2541–50.