Chromogranin A

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Chromogranin A is localized in secretory granules of neurons and endocrine cells in tissues, including pituitary, adrenal medulla, thyroid, pancreatic islets and gastrointestinal tract. Neuroendocrine cells exhibit a fine granular immunoreactivity to Anti-Chromogranin A. It is widely recognized that co-expression of keratins and chromogranin A implies a neuroendocrine lineage. High expression of Chromogranin A and negative staining with Anti-Keratin is a possible indication of paraganglioma. Positive staining for Chromogranin A and neuron-specific enolase is representative of neuroendocrine neoplasms. Many pituitary adenomas and prolactinomas stains positively for Chromogranin A.
  • References
    1. Helman LJ, et al. J Biol Chem. 1988; 263:11559–63.
    2. Iacangelo AL, et al. Regul Pept. 1995; 58: 65–88.
    3. Hendy GN, et al. Clin Invest Med. 1995; 18:47–65.
    4. Kokubo H, et al. Urology. 2005; 66:135-40.
    5. Conlon JM, et al. Regul Pept. 2010; 165:5-11.


Clone IHC544
Source Mouse Monoclonal
Positive Control Pancreas
Dilution Range 1:50-1:200