GeneAb™

Claudin-1

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Cat. No.

IHC545-100

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Description

Claudin-1 is a component of tight junctions which regulates permeability in epithelial and endothelial cell sheets. Anti-Claudin-1 staining localizes to the membrane and is found in almost all carcinomas, which produce a stronger staining intensity than normal tissues. A panel of antibodies against Claudin-1, EMA(+), S-100(-), and GLUT1 is useful for diagnosing perineurioma and neurofibroma. As Claudin-1 is also present in meningiomas, staining for claudin 1, S-100, CD34, EMA, and glial fibrillary acidic protein (GFAP) in concert could be useful in distinguishing meningiomas from histologically similar samples.
  • References
    1. Folpe AL, et al. Am J Surg Pathol. 2002; 26:1620-6.
    2. Hornick JL, et al. Am J Surg Pathol. 2005; 29:845-58.
    3. Soini Y. Histopathology. 2005; 47:551-60.
    4. Smith ME, et al. Histopathology. 2005; 47:575-81.
    5. Liu Y, et al. Lung Cancer. 2007; 56:307-17.
    6. Macarenco RS, et al. Arch Pathol Lab Med. 2007; 131:625-36.

Specifications

Clone IHC545
Source Mouse Monoclonal
Positive Control Neurofibroma, Colon Carcinoma
Dilution Range 1:50-1:200

Literature