GeneAb™

Claudin-1

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$135.00

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Cat. No.

IHC545-100

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Description

Claudin-1 is a component of tight junctions which regulates permeability in epithelial and endothelial cell sheets. Anti-Claudin-1 staining localizes to the membrane and is found in almost all carcinomas, which produce a stronger staining intensity than normal tissues. A panel of antibodies against Claudin-1, EMA(+), S-100(-), and GLUT1 is useful for diagnosing perineurioma and neurofibroma. As Claudin-1 is also present in meningiomas, staining for claudin 1, S-100, CD34, EMA, and glial fibrillary acidic protein (GFAP) in concert could be useful in distinguishing meningiomas from histologically similar samples.

Specifications

Clone IHC545
Source Mouse Monoclonal
Positive Control Neurofibroma, Colon Carcinoma
Dilution Range 1:100 - 1:200

References

  1. Folpe AL, et al. Am J Surg Pathol. 2002; 26:1620-6.
  2. Hornick JL, et al. Am J Surg Pathol. 2005; 29:845-58.
  3. Soini Y. Histopathology. 2005; 47:551-60.
  4. Smith ME, et al. Histopathology. 2005; 47:575-81.
  5. Liu Y, et al. Lung Cancer. 2007; 56:307-17.
  6. Macarenco RS, et al. Arch Pathol Lab Med. 2007; 131:625-36.