Cytokeratin 20

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Cytokeratin 20 (CK20) forms intermediate filaments and is normally present in gastric and intestinal epithelium, urothelium, and Merkel cells. Anti-Cytokeratin 20 is used for distinguishing specific types of urinary tract epithelial cells and malignant epithelia. Anti-Cytokeratin 20 stains tissues of the colon, stomach, pancreas, biliary system adenocarcinomas, transitional-cell, mucinous ovarian tumors, and Merkel cell carcinomas. Non-mucinous tumors of the ovary, and breast, lung, squamous cell, small cell, and endometrium adenocarcinomas are not stained by Anti-Cytokeratin 20.
  • References
    1. Ordonez NG. Am J Surg Pathol. 1998; 22:1203-14.
    2. Cury PM, et al. Mod Pathol. 2000; 13:107-12.
    3. Chu PG, et al. Mod Pathol. 2002; 15:6-10.
    4. Ordonez NG. Am J Surg Pathol. 1998; 22:1215-21.
    5. Lin L, et al. J Cutan Pathol. 2003; 30:114-7.
    6. Sigel JE, et al. J Cutan Pathol. 2001; 28:520-4.
    7. Abarahams NA, et al. Am J Clin Pathol. 2003; 120:368-76.
    8. Reis-Filho JS, et al. Virchows Arch. 2003; 443:122-32.
    9. Lacroix-Triki M, et al. Virchows Arch. 2003; 442:548-54.
    10. Otterbach F, et al. Histopathology. 2000; 37:232-40


Clone IHC020
Source Mouse Monoclonal
Positive Control Colon Carcinoma
Dilution Range 1:50-1:200