Cytokeratin 5 & 6

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Cytokeratin 5 dimerizes with Cytokeratin 14 to form the cytoskeleton of basal epithelial cells, while Cytokeratin 6 multimerizes with Cytokeratin 16 and/or 17 in the tongue, oral epithelia and esophagus, hair follicles, and glandular epithelia. Anti-Cytokeratin 5 & 6 rarely stains lung adenocarcinoma, but will produce small foci or scattered staining patterns in these Cytokeratin 5 & 6(+) samples. Cytokeratin 5 & 6 staining is useful for identifying squamous cell carcinoma, and can be used to determine the malignancies of myoepithelial cells in the breast and prostate. Cytokeratin 5 & 6 also rarely stains carcinomas of the breast, colon, and prostate. A panel of antibodies against Cytokeratin 5 & 6, TTF-1, napsin A, p63, SOX-2, DSC3, and desmoglein-3 is useful for differentiating lung squamous cell carcinoma from lung adenocarcinoma and large cell carcinoma.
  • References
    1. Moll R, et al. Cell. 1982; 31:11-24.
    2. Lersch R, et al. Mol Cell Biol. 1988; 8:486–93.
    3. Clover J, et al. Histopathology. 1997; 31:140-3.
    4. Otterbach F, et al. Histopathology. 2000; 37:232-40.
    5. Chu P, et al. Mod Pathol. 2002; 15:6-10.


Clone IHC556
Source Mouse Monoclonal
Positive Control Mesothelioma
Dilution Range 1:50-1:200