Cytokeratin 7

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Cytokeratin 7 (CK7) is a type II keratin which is present in transitional, ductal, glandular, and biliary duct epithelial cells. Cytokeratin 7 is a useful marker for distinguishing between carcinomas of the lung, breast, endometrium, and urothelia (positive stain) from carcinomas of the colon and prostate (negative stain). Cytokeratin 7 is present is nearly all primary lung adenocarcinomas, and is a useful marker in the differential diagnosis of ovarian neoplasms. Anti-Cytokeratin 7 does not stain intermediate filament.
  • References
    1. Jerome MV, et al. Histopathology. 2004; 45:125-34.
    2. Murray SK, et al. Am J Surg Pathol. 2004; 28:1154-62.
    3. Chu P, et al. Mod Pathol. 2000; 13:962-72.
    4. Logani S, et al. Am J Surg Pathol. 2003; 27:1434-41.
    5. Ramalingam P, et al. Ann Diagn Pathol. 2003; 7:112-9.
    6. Roy S, et al. Arch Pathol Lab Med. 2011; 135:1601-5.
    7. Han AC, et al. Cancer. 1999; 86:2327-30.
    8. McCluggage WG, et al. Histopathology. 2005; 47:231-47.


Clone IHC007
Source Mouse Monoclonal
Positive Control Salivary Gland, Lung Adenocarcinoma
Dilution Range 1:50-1:200