GeneAb™

Cytokeratin 8 & 18

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$120.00

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Cat. No.

IHC558-100

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Description

Cytokeratin 8 & 18 (CK8 & 18) are present in various epithelia including that of the breast, thyroid, respiratory tract, and gastrointestinal tract. Anti-Cytokeratin 8 & 18 stains adenocarcinomas and most non-keratinizing squamous carcinomas, but does not stain keratinizing squamous carcinomas. Since Cytokeratin 18 is scarce in normal epidermis, Anti-Cytokeratin 8 & 18 is used to detect Paget cells in such samples. Cytokeratin 8 & 18 staining helps identify colorectal carcinoma metastases as it is more sensitive than genetic tests.

Specifications

Clone IHC558
Source Mouse Monoclonal
Positive Control Prostate, Pancreas
Dilution Range 1:100 - 1:200

References

  1. Angus B, et al. J Pathol. 1987; 155:377- 84.
  2. Corson, JM. Pathol Annu. 1986; 21:47-81.
  3. Liegl B, et al. Histopathology. 2007; 50:439-47.
  4. Sasaki M, et al. Histopathology. 1998; 32:199-208.