Cytokeratin 8 & 18 (In the pipeline)
Cytokeratin 8 & 18 (CK8 & 18) are present in various epithelia including that of the breast, thyroid, respiratory tract, and gastrointestinal tract. Anti-Cytokeratin 8 & 18 stains adenocarcinomas and most non-keratinizing squamous carcinomas, but does not stain keratinizing squamous carcinomas. Since Cytokeratin 18 is scarce in normal epidermis, Anti-Cytokeratin 8 & 18 is used to detect Paget cells in such samples. Cytokeratin 8 & 18 staining helps identify colorectal carcinoma metastases as it is more sensitive than genetic tests.
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