Ep-CAM/Epithelial Specific Antigen

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Epithelial Cell Adhesion Molecule (EpCAM) is a transmembrane glycoprotein that mediates cell–cell adhesion in epithelia. It is normally present on most baso-lateral surfaces of normal epithelial cells and is absent in myoepithelial cells, hepatocytes, adult squamous epithelia, mesothelial cells, and fibroblasts. Anti-EpCAM stains most adenocarcinomas and neuroendocrine tumors, including small cell carcinomas. A minority of renal clear cell carcinoma, renal oncocytoma, and hepatocellular carcinoma stain positively for EpCAM, while Anti-EpCAM stains nearly all basal cell carcinoma. Anti-EpCAM stains chromophobe renal cell carcinoma, papillary renal cell carcinoma, and cholangiocarcinoma more frequently. Anti-EpCAM can be useful for distinguishing malignancy in the peritoneal and pleural cavities.
  • References
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    4. Ordóñez NG. Mod Pathol. 2006; 19:417-28.
    5. Tope WD, et al. Dermatol Surg. 2000; 26:415-8.
    6. Ordóñez NG. Adv Anat Pathol. 2006; 13:16-25.
    7. Ordóñez NG. Am J Clin Pathol. 1998; 109:85-9.


Clone IHC567
Source Mouse Monoclonal
Positive Control Colon Adenocarcinoma
Dilution Range 1:50-1:200