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Description

Epithelial Cell Adhesion Molecule (EpCAM) is a transmembrane glycoprotein that mediates cell–cell adhesion in epithelia. It is normally present on most baso-lateral surfaces of normal epithelial cells and is absent in myoepithelial cells, hepatocytes, adult squamous epithelia, mesothelial cells, and fibroblasts. Anti-EpCAM stains most adenocarcinomas and neuroendocrine tumors, including small cell carcinomas. A minority of renal clear cell carcinoma, renal oncocytoma, and hepatocellular carcinoma stain positively for EpCAM, while Anti-EpCAM stains nearly all basal cell carcinoma. Anti-EpCAM stains chromophobe renal cell carcinoma, papillary renal cell carcinoma, and cholangiocarcinoma more frequently. Anti-EpCAM can be useful for distinguishing malignancy in the peritoneal and pleural cavities.

• References

  1. Schnell U, et al. 2013; 1828:1989-2001.
  2. Latza, et al. J Clin Pathol. 1990; 43:213-19.
  3. Ma CK, et al. Am J Clin Pathol. 1993; 99:551-7.
  4. Ordóñez NG. Mod Pathol. 2006; 19:417-28.
  5. Tope WD, et al. Dermatol Surg. 2000; 26:415-8.
  6. Ordóñez NG. Adv Anat Pathol. 2006; 13:16-25.
  7. Ordóñez NG. Am J Clin Pathol. 1998; 109:85-9.

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Literature