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Fascin is an actin cross-linking protein associated with cell motility. Fascin is detectable in dendritic cells, Reed-Sternberg cells, nodular sclerosis variants, mixed cellularity, and lymphocyte depletion in Hodgkin's disease, while being undetectable in lymphoid cells, plasma cells, and myeloid cells. Anti-Fascin is useful for differentiating between Hodgkin’s and non-Hodgkin lymphoma. As Fascin is absent in neoplastic follicles in follicular lymphoma, Anti-Fascin is useful for differentiating these lymphomas from reactive follicular hyperplasia where the number of follicular dendritic cells are normal or increased.


Clone IHC573
Source Mouse Monoclonal
Positive Control Hodgkin Lymphoma
Dilution Range 1:100 - 1:200


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