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Fascin is an actin cross-linking protein associated with cell motility. Fascin is detectable in dendritic cells, Reed-Sternberg cells, nodular sclerosis variants, mixed cellularity, and lymphocyte depletion in Hodgkin's disease, while being undetectable in lymphoid cells, plasma cells, and myeloid cells. Anti-Fascin is useful for differentiating between Hodgkin’s and non-Hodgkin lymphoma. As Fascin is absent in neoplastic follicles in follicular lymphoma, Anti-Fascin is useful for differentiating these lymphomas from reactive follicular hyperplasia where the number of follicular dendritic cells are normal or increased.
  • References
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    3. Goncharuk VN, et al. J Cutan Pathol. 2002; 29:430-8.
    4. Kempf W, et al. J Cutan Pathol. 2002; 29:295-300.
    5. Kraus MD, et al. Am J Dermatopathol. 2001; 23:104-11.
    6. Hu W, et al. Clin Exp Metastasis. 2000; 18:83-8.
    7. Chu PG. Ann Diagn Pathol. 1999; 3:104-33.
    8. Grothey A, et al. Br J Cancer. 2000; 83:870-3.


Clone IHC573
Source Mouse Monoclonal
Positive Control Hodgkin Lymphoma
Dilution Range 1:50-1:200