GeneAb™

Fli-1

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$165.00

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Cat. No.

IHC576-100

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Description

Friend leukemia integration 1 (Fli-1) is a transcription factor involved in cellular proliferation and tumorigenesis, which is normally expressed in endothelial and hematopoietic cells, including T lymphocytes. Anti-Fli-1 is a valuable tool in the discrimination of Ewing sarcoma/peripheral primitive neuroectodermal tumor (ES/PNET) from most of its potential mimics. Most cases of ES/PNET are characterized by a chromosomal translocation resulting in a fusion oncoprotein and aberrant transcription factor EWS/Fli-1. Fli-1 has been found to play an important role in the embryologic development of blood vessels, and is specifically expressed in adult endothelial cells in all types of blood vessels, as well as in both benign and malignant vascular tumors.

Specifications

Clone IHC576
Source Mouse Monoclonal
Positive Control Primitive Neuroectodermal Tumor
Dilution Range 1:100 - 1:200

References

  1. Rao VN, et al. Oncogene. 1993; 8:2167–73.
  2. Mhawech-Fauceglia P, et al. Histopathology. 2006; 49:569-75.
  3. Ohno T, et al. Cancer Res. 1993; 53:5859–63.
  4. Ellison DA, et al. Hum Pathol. 2007; 38:205-11.