GeneAb™

GATA3

Select Format:

Select Volume:

Price:

$195.00

Quantity:

Cat. No.

IHC583-100

Inquire

Description

GATA3 is a transcription factor important in cell proliferation, development, and differentiation. GATA3 is mostly observed in breast and urothelial carcinomas, and rarely present in other cancers such as endometrial endometrioid adenocarcinoma. Among the breast carcinomas, GATA3 has a lower expression in luminal B subtype breast carcinoma. Studies have found GATA3 expression to be associated with ER (estrogen receptor), PR (progesterone receptor), and Her2 in breast cancer cases. Urothelial carcinomas stain positively for GATA3 in invasive or high grade tumors, therefore Anti-GATA3 is useful for carcinoma diagnosis when breast and bladder are plausible.

Specifications

Clone IHC583
Source Mouse Monoclonal
Positive Control Breast Carcinoma, Urothelial Carcinoma
Dilution Range 1:100 - 1:200

References

  1. Higgins JP, et al. Am J Surg Pathol. 2007; 31:673-80.
  2. Liu H, et al. Am J Clin Pathol. 2012; 138:57-64.