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Glypican-3 (GPC3) is a GPI-archored proteoglycan involved in cell division and growth regulation. Glypican-3 is a useful tumor marker, and its expression has been shown to be upregulated in hepatocellular carcinoma (HCC), hepatoblastoma, melanoma, testicular germ cell tumors, and Wilms’ tumor. Patients with HCC have presented elevated levels of GPC3 in the neoplastic liver tissues and serum, which is higher than cirrhotic liver or liver with focal lesions including those with hepatic adenoma and dysplastic nodules. Glypican-3 is also overexpressed in testicular germ cell tumors of certain subtypes, such as yolk sac tumors and choriocarcinoma, and in embryonal tumors.
  • References
    1. Capurro M, et al. Gastroenterology. 2003; 125:89-97.
    2. Coston WMP, et al. Am J Surg Pathol. 2008; 32:433-44.
    3. Kandil D, et al. Cancer. 2007; 111:316-22.
    4. Zynger DL, et al. Hum Pathol. 2008; 39:224-30.
    5. Kandil DH, et al. Adv Anat Pathol. 2009; 16:125-9.
    6. Zynger DL, et al. Am J Surg Pathol. 2006; 30:1570-5.


Clone IHC405
Source Mouse Monoclonal
Positive Control Hepatocellular Carcinoma
Dilution Range 1:50-1:200