Human Germinal center-Associated Lymphoma (HGAL) protein, also known as Germinal Center-associated Lymphoma Protein or GCET, is expressed specically in the cytoplasm of germinal center B-cells. As HGAL is absent in mantle and marginal zone B-cells, and in the interfollicular and paracortical regions of normal tonsils and lymph nodes, this protein is an optimal prognostic marker for B cell lymphomas derived from germinal centers, as well as follicular lymphoma. HGAL expression is also indicative of a subset of Hodgkin’s lymphoma of germinal center derivation and improved survival, and predicts the outcome in patients with diuse large B-cell lymphoma.
CLONE:
IHC598
ISOTYPE:
HOST SPECIES:
Mouse
CLONALITY:
Monoclonal
POSITIVE CONTROL:
Tonsil, Lymph node
DILUTION RANGE:
INTENDED USE/REG. STATUS:
IVD