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GeneAb™

Description

Human Germinal center-Associated Lymphoma (HGAL) protein, also known as Germinal Center-associated Lymphoma Protein or GCET, is expressed specifically in the cytoplasm of germinal center B-cells. As HGAL is absent in mantle and marginal zone B-cells, and in the interfollicular and paracortical regions of normal tonsils and lymph nodes, this protein is an optimal prognostic marker for B cell lymphomas derived from germinal centers, as well as follicular lymphoma. HGAL expression is also indicative of a subset of Hodgkin’s lymphoma of germinal center derivation and improved survival, and predicts the outcome in patients with diffuse large B-cell lymphoma.

• References

  1. Natkunam Y, et al. Blood. 2005; 105:3979-86.
  2. Natkunam Y, et al. Blood. 2007; 109:298-305.
  3. Younes SF, et al. Am J Surg Pathol. 2010; 34:1266-76.
  4. Higgins RA, et al. Arch Pathol Lab Med. 2008; 132:441-6.
  5. Steinke JW, et al. Mol Immunol. 2004; 41:1145-53.
  6. Lossos IS, et al. Blood. 2003; 101:433-40.
  7. Azambuja D, et al. Leuk Lymphoma. 2009; 50:1830-6.

Specifications

Literature