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HMB-45 is specific for an antigen present in immature melanosomes, cutaneous melanocytes, and prenatal and infantile retinal pigment epithelium cells. It is therefore effective for identifying malignant melanoma, and differentiating metastatic amelanotic melanoma from a number of conditions from which the discrimination is often extremely difficult, including large cell lymphomas, sarcomas, spindle cell carcinomas, and various types of mesenchymal neoplasms. This antibody can also differentiate between junctional nevus and intradermal nevus cells, and fetal or neonatal melanocytes versus normal adult melanocytes.
  • References
    1. Gown AM, et al. Am J Pathol. 1986; 123:195-203.
    2. Wick MR, et al. Arch Pathol Lab Med. 1988; 112:616-20.
    3. Leong ASY, et al. Surg Path. 1989; 2:137-45.
    4. Blessing K, et al. Histopathology. 1998; 32:139-46.
    5. Jungbluth AA, et al. Am J Surg Pathol. 1998; 22:595-602.
    6. Beaty MW, et al. Cancer. 1997; 81:57-63.
    7. Bonetti F, et al. Amer J Clin Pathol 1991; 95:454-9.
    8. Ordonez NG, et al. Amer J Clin Pathol 1988; 90:385-90.


Clone IHC602
Source Mouse Monoclonal
Positive Control Melanoma
Dilution Range 1:50-1:200