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The Insulin-like Growth Factor 1 Receptor, also known as IGF-1R or IGF1R, is a transmembrane protein belonging to the tyrosine kinase receptor family. Upon activation by Insulin-like Growth Factor 1 (IGF-1), the receptor enhances cell survival through stimulation of mitosis and inhibition of apoptosis. The IGF-1R is highly overexpressed in malignant tissues, and is clinically implicated in a number of cancers, including those of the breast, prostate, and lung. Studies have shown IGF-1R to be associated with poor prognosis in breast cancer, and, when co-expressed with epidermal growth factor receptor (EGFR), IGF-1R has been linked with shorter disease free survival in resected non-small-cell lung cancer patients.
  • References
    1. Warshamana-Greene GS, et al. Clin Cancer Res. 2005; 11:1563-71.
    2. Jones HE et al. Endocr Relat Cancer. 2004; 11:793-814.
    3. Appleby PN, et al. Lancet Oncol. 2010; 11:530-42.
    4. Scartozzi M, et al. Int J Cancer. 2010; 127:1941-7.
    5. Ludovini V. Ann Oncol. 2009; 20:842-9.
    6. Creighton CJ, et al. J Clin Oncol. 2008; 26:4078-85.
    7. Fukuda R, et al. J Biol Chem. 2002; 277:38205-11.


Clone IHC605
Source Mouse Monoclonal
Positive Control Colon Cancer, Breast Cancer, Lung Squamous Cell Carcinoma
Dilution Range 1:50-1:200