IGF-1R(In the pipeline)
The Insulin-like Growth Factor 1 Receptor, also known as IGF-1R or IGF1R, is a transmembrane protein belonging to the tyrosine kinase receptor family. Upon activation by Insulin-like Growth Factor 1 (IGF-1), the receptor enhances cell survival through stimulation of mitosis and inhibition of apoptosis. The IGF-1R is highly overexpressed in malignant tissues, and is clinically implicated in a number of cancers, including those of the breast, prostate, and lung. Studies have shown IGF-1R to be associated with poor prognosis in breast cancer, and, when co-expressed with epidermal growth factor receptor (EGFR), IGF-1R has been linked with shorter disease free survival in resected non-small-cell lung cancer patients.
|Positive Control||Colon Cancer, Breast Cancer, Lung Squamous Cell Carcinoma|
|Dilution Range||1:100 - 1:200|