INI-1(In the pipeline)
Integrase interactor 1 (INI-1), also known as hSNF5, is an integral component of the hSWI/SNF (SWItch/Sucrose Non-Fermentable) chromatin remodeling complex, which facilitates DNA-dependent cellular processes including transcription, replication, and repair. The INI-1 gene is often mutated or deleted in malignant rhabdoid tumor (MRT), a tumor which is potentially mimicked by medulloblastoma and supratentorial primitive neuroectodermal tumors (sPNETs). The morphology of MRTs can often present challenges in differential diagnosis, and INI-1 has shown to be useful in distinguishing between the three conditions as the majority of medulloblastomas and sPNETs are labeled by Anti-INI-1, while a lack of nuclear labeling by the same antibody is characteristic of MRT.
|Positive Control||Brain, Endothelial Cells, Astrocytoma|
|Dilution Range||1:100 - 1:200|