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Integrase interactor 1 (INI-1), also known as hSNF5, is an integral component of the hSWI/SNF (SWItch/Sucrose Non-Fermentable) chromatin remodeling complex, which facilitates DNA-dependent cellular processes including transcription, replication, and repair. The INI-1 gene is often mutated or deleted in malignant rhabdoid tumor (MRT), a tumor which is potentially mimicked by medulloblastoma and supratentorial primitive neuroectodermal tumors (sPNETs). The morphology of MRTs can often present challenges in differential diagnosis, and INI-1 has shown to be useful in distinguishing between the three conditions as the majority of medulloblastomas and sPNETs are labeled by Anti-INI-1, while a lack of nuclear labeling by the same antibody is characteristic of MRT.
  • References
    1. Bourdeaut F, et al. J Pathol. 2007; 211:323-30.
    2. Fowler DJ, et al. Fetal PediX Pathol. 2006; 25:159-68.
    3. Haberler C, et al. Am J Surg Pathol. 2006; 30:1462-8.
    4. Hornick JL, et al. Am J Surg Pathol. 2009; 33:542-50.
    5. Das S. Curr Protein Pept Sci. 2015; 16:478-90.


Clone IHC608
Source Mouse Monoclonal
Positive Control Brain, Endothelial Cells, Astrocytoma
Dilution Range 1:50-1:200