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Insulin is a polypeptide hormone produced by the pancreas in the beta cells of the Islets of Langerhans. Its biological functions include regulating the storage and release of glucose, as well as promoting glycogen storage, triglyceride formation, and protein synthesis. Insulin has been clinically indicated in a number of conditions, including tumors of beta cell origin. The presence of insulin in the cytoplasm of islet cell tumors is indicative of functional insulinomas, while a deficiency of insulin results in diabetes mellitus.
  • References
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    2. Scully RE, et al. N Eng J Med. 1983; 308:30-7.
    3. Erlandsen SL. Williams and Wilkins Baltimore. 1980: 140-55.
    4. Friesen SR. N Eng J Med. 1982; 306:580-90.
    5. Jorda M, et al. Arch Pathol Lab Med. 2003; 127:196-9.
    6. Letizia C, et al. Eur J Endocrinol. 2001; 144:517-20.
    7. Govindarajan M, et al. Diabetes Res Clin Pract. 2001; 51:29-38.
    8. Azzoni C, et al. Virchows Arch. 1998; 433:495-504.
    9. Lubensky IA, et al. Am J Pathol. 1998; 153:223-31.


Clone IHC609
Source Mouse Monoclonal
Positive Control Pancreas
Dilution Range 1:50-1:200