GeneAb™

Kappa

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Cat. No.

IHC610-100

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Description

Anti-Kappa recognizes surface immunoglobulin on normal and neoplastic B-cells, and has been indicated as a potential aid in the identification of leukemias, plasmacytomas, and certain non-Hodgkin’s lymphomas, where the expression of a single light chain class is restricted. The determination of light chain ratio is critical in evaluating B-cell neoplasms, as the majority of B-cell lymphomas express either kappa or lambda light chains, while a mixture of kappa and lambda is characteristic of reactive proliferations. In paraffin-embedded tissue, Anti-Kappa displays strong staining of kappa-positive plasma cells, as well as cells that have absorbed exogenous immunoglobulins.

Specifications

Clone IHC610
Source Mouse Monoclonal
Positive Control Tonsil
Dilution Range 1:100 - 1:200

References

  1. Bray M, et al. Am J Clin Pathol. 1983; 80:526-8.
  2. Ashton-Key M, et al. Histopathology. 1996; 29:525-31.
  3. Kurtin PJ, et al. Am J Clin Pathol. 1999; 112:319-29.
  4. Falini B, et al. J Histochem Cytochem. 1982; 30:21-6.
  5. Marshall-Taylor CE, et al. Appl Immunohistochem Mol Morphol. 2002; 10:258-62.
  6. Sobol RE, et al. Clin Immunol Immunopathol. 1982; 24:139 -44.
  7. Samoszuk MK, et al. Diagn Immunol. 1985; 3:133-8.
  8. Abbondanzo SL, et al. Ann Diagn Pathol. 1999; 3:318-27.