Ksp-cadherin (In the pipeline)
Ksp-cadherin, also known as kidney-specific cadherin, is a cell adhesion molecule that is found exclusively in the basolateral membrane of renal tubular epithelial cells and collecting duct cells of the kidney, but not in glomerulus, renal interstitial cells, nor blood vessels. Ksp-cadherin has been identified as a potentially useful marker in differentiating between chromophobe renal-cell carcinoma and oncocytoma, as one study has found a membranous pattern of staining in 96% of 30 chromophobe carcinomas, and in only 6% of 31 oncocytomas. Cadherins have also been investigated in renal cell cancers, demonstrating that a loss of cadherins is potentially correlated to tumor differentiation and the presence of lymph node metastasis.
||1:100 - 1:200
- Mazal PR, et al. Hum Pathol. 2005; 36:22-8.
- Shen SS, et al. Mod Pathol. 2005; 18:933-40.
- Thedieck C, et al. Br J Cancer. 2005; 92:2010-7.