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Lymphoid Enhancer-binding Factor 1 (LEF-1) is a nuclear protein with an important role in lymphopoiesis, which is normally expressed in T cells and pre-B cells, but not in mature B cells. LEF-1 is a member of a family of regulatory proteins that share homology with the high mobility group protein 1, and is also part of the LEF/TCF transcription factor family which has been shown to play an important role in regulating the Wnt-pathway target genes that are essential for survival and proliferation. LEF-1 plays a crucial role in many human cancers, and its overexpression has been shown to be associated with disease progression and poor prognosis in B-cell chronic lymphocytic leukemia, making it a potentially suitable immunohistochemical marker for diagnosis of this condition. LEF-1 has also been linked to high grade follicular lymphoma and diffuse large B-cell lymphoma, whereas a similar link has not been found in mantle cell lymphoma or marginal zone lymphoma. High levels of LEF-1 have also recently been demonstrated as a favorable prognostic marker in cytogenetically normal acute myeloid leukemia.
  • References
    1. Milatovich A, et al. Genomics. 1992; 11:1040–8.
    2. Erdfelder F, et al. Hematol Rep. 2010; 2:e3.
    3. Boras-Granic K, et al. Dev Biol. 2006; 295:219-31.
    4. Gandhirajan RK, et al. Neoplasia. 2010; 12:326-35.
    5. Tandon B, et al. Mod Pathol. 2011; 24:1433-43.
    6. Wang SH, et al. BMC Gastroenterol. 2012; 12: 53.


Clone IHC614
Source Mouse Monoclonal
Positive Control Tonsil, Lymphocytic Lymphoma
Dilution Range 1:50-1:200