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Langerin is a type II, C-type (Ca2+-dependent) transmembrane lectin that is localized in the Birbeck granules of Langerhans cells. This marker has proven helpful in differentiating Langerhans cell histiocytosis from other non-Langerhans cell histiocytic proliferations, as evaluation of langerin expression is valuable in circumstances where a diagnosis of Langerhans cell histiocytosis is suspected, but cannot be confirmed due to lack of CD1a immunoreactivity. Anti-Langerin is also useful as part of a panel of antibodies against CD1a, CD21, CD23, CD35, and S-100, in the distinction of histiocytic sarcoma, interdigitating dendritic cell sarcoma, follicular dendritic cell sarcoma, disseminated juvenile xanthogranuloma, and Rosai-Dorfman disease (sinus histiocytosis with massive lymphadenopathy).
  • References
    1. De Witte L, et al. Nat Med. 2007; 13:367-71.
    2. Park L, et al. J Cutan Med Surg. 2012; 1:45-9.
    3. Lau SK, et al. Am J Surg Pathol. 2008; 32:615-9.
    4. Turville S, et al. J Leukoc Biol. 2003; 74:710-8.
    5. Valladeau J, et al. Immunity. 2000; 12:71-81.
    6. Valladeau J, et al. J Immunol. 2002; 168:782-92.
    7. Demellawy DE, et al. Pathology. 2015; 4:294-301.


Clone IHC613
Source Mouse Monoclonal
Positive Control Langerhans Cell Histiocytosis
Dilution Range 1:50-1:200