GeneAb™

Lp-PLA2

(In the pipeline)

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$210.00

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Cat. No.

IHC407-100

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Description

Lp-PLA2, also known as Lipoprotein-associated Phospholipase A2 or platelet-activating factor acetylhydrolase (PAF-AH), is an enzyme produced by inflammatory cells that functions to inactivate and degrade platelet-activating factor, a potent pro-inflammatory phospholipid, while also being responsible for hydrolyzing oxidatively modified polyunsaturated fatty acids. The products of the enzymatic actions of Lp-PLA2 have been linked to the development of atherosclerosis, and are positively correlated with increased risk of coronary heart disease and stroke. This marker has recently been studied as a therapeutic target for cardiac diseases.

Specifications

Clone IHC407
Source Mouse Monoclonal
Positive Control Tonsil, Thymus, Placenta
Dilution Range 1:100 - 1:200

References

  1. Carlquist JF, et al. Expert Rev Mol Diagn. 2007; 7:511-7.
  2. Zalewski A, et al. Arterioscler Thromb Vasc Biol. 2005; 25:923-31.
  3. Tjoelker LW, et al. Nature. 1995; 374:549-53.
  4. Mohler ER, et al. J Am Coll Cardiol. 2008; 51:1632-41.
  5. The Lp-PLA2 Studies Collaboration. Lancet. 2010; 375:1536-44.