GeneAb™

MDM2

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$105.00

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Cat. No.

IHC620-100

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Description

Mouse Double Minute 2 homolog (MDM2), also known as HDM2 in humans, is crucial in negative regulation of the p53 tumor suppressor. Negative regulation is mediated through both the ubiquitination of p53/TP53, as well as inhibition of p53 transcriptional activation. Reports have indicated an overexpression of MDM2 to be associated with a number of different human tumor types, including soft tissue sarcomas, osteosarcomas, and breast tumors. When co-overexpressed with the CDK4 protein, MDM2 can also aid in the detection of well differentiated liposarcomas and dedifferentiated liposarcoma.

Specifications

Clone IHC620
Source Mouse Monoclonal
Positive Control Breast Carcinoma
Dilution Range 1:100 - 1:200

References

  1. Oliner JD, et al. Nature. 1992; 358:80–3.
  2. Wade M, et al. J Biol Chem. 2006; 281:33036–44.
  3. Aleixo PB, et al. J Clin Pathol. 2009; 62:1127-35.