GeneAb™

MDM2

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Cat. No.

IHC620-100

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Description

Mouse Double Minute 2 homolog (MDM2), also known as HDM2 in humans, is crucial in negative regulation of the p53 tumor suppressor. Negative regulation is mediated through both the ubiquitination of p53/TP53, as well as inhibition of p53 transcriptional activation. Reports have indicated an overexpression of MDM2 to be associated with a number of different human tumor types, including soft tissue sarcomas, osteosarcomas, and breast tumors. When co-overexpressed with the CDK4 protein, MDM2 can also aid in the detection of well differentiated liposarcomas and dedifferentiated liposarcoma.
  • References
    1. Oliner JD, et al. Nature. 1992; 358:80–3.
    2. Wade M, et al. J Biol Chem. 2006; 281:33036–44.
    3. Aleixo PB, et al. J Clin Pathol. 2009; 62:1127-35.

Specifications

Clone IHC620
Source Mouse Monoclonal
Positive Control Breast Carcinoma
Dilution Range 1:50-1:200

Literature