GeneAb™

MDR3

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$210.00

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Cat. No.

IHC621-100

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Description

Multidrug Resistance 3 (MDR3), also known as ATP Binding Cassette Subfamily B Member 4 (ABCB4), is a membrane-associated protein belonging to the superfamily of ATP-binding cassette transporters. MDR3 is an energy-dependent phospholipid efflux translocator that mediates the translocation of phosphatidylcholine across the canalicular membrane of the hepatocyte, and also acts as a positive regulator of biliary lipid secretion. Defects in MDR3 are associated with progressive familial intrahepatic cholestasis type 3 and gallbladder disease type 1. Co-overexpression of MDR3 and MRP1 has been documented as correlating with blastemal subtype and high-risk prognosis of Wilms’ tumor patients.

Specifications

Clone IHC621
Source Mouse Monoclonal
Positive Control Adrenal Cortex
Dilution Range 1:100 - 1:200

References

  1. Hontecillas-Prieto L, et al. Oncotarget. 2017; 8:11173-86.
  2. van Helvoort A, et al. Cell. 1996; 87:507-17.
  3. Morita SY, et al. Hepatology. 2007; 46:188-99.
  4. Crawford AR, et al. J Clin Invest. 1997; 100:2562-7.
  5. de Vree JML, et al. Proc Natl Acad Sci U S A. 1998; 95.
  6. Rosmorduc O, et al. Gastroenterology. 2001; 120:1459-67.