GeneAb™

MLH1

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$165.00

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Cat. No.

IHC409-100

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Description

MutL Homolog 1 (MLH1) is a protein involved in the mismatch-repair pathway. This protein is commonly associated with hereditary non-polyposis colorectal cancer, as the MLH1 gene is frequently mutated in patients with this cancer. Studies have shown MLH1 to be deficient in a high percentage of patients with microsatellite instability, as well as endometrial and ovarian cancers. Use of Anti-MLH1 is optimized when paired in an IHC panel with MSH6, MSH2, and PMS2. Anti-MLH1 is useful in the detection of MLH1 in a number of normal and neoplastic tissues, and for identifying a loss of MLH1 in tumors that are microsatellite-unstable.

Specifications

Clone IHC409
Source Mouse Monoclonal
Positive Control Colon, Colon Carcinoma
Dilution Range 1:100 - 1:200

References

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  8. Wahlberg SS, et al. Cancer Res. 2002: 62:3485-92.
  9. Lanza G, et al. Mod Pathol. 2002; 15:741-9.