Select Format:

Select Volume:




Cat. No.




MutL Homolog 1 (MLH1) is a protein involved in the mismatch-repair pathway. This protein is commonly associated with hereditary non-polyposis colorectal cancer, as the MLH1 gene is frequently mutated in patients with this cancer. Studies have shown MLH1 to be deficient in a high percentage of patients with microsatellite instability, as well as endometrial and ovarian cancers. Use of Anti-MLH1 is optimized when paired in an IHC panel with MSH6, MSH2, and PMS2. Anti-MLH1 is useful in the detection of MLH1 in a number of normal and neoplastic tissues, and for identifying a loss of MLH1 in tumors that are microsatellite-unstable.
  • References
    1. Pal T, et al. Cancer. 2008; 113:733-42.
    2. Wright CL, et al. Am J Surg Pathol. 2003; 27:1393-1406.
    3. Brueckl WM, et al. Anticancer Res. 2003: 23:1773-8.
    4. Rigau V, et al. Arch Pathol Lab Med. 2003; 127:694-700.
    5. Renkonen E, et al. J Clin Oncol. 2003; 21:3629-37.
    6. Hoedema R, et al. Am Surg. 2003; 69:387-92.
    7. Christensen M, et al. Cancer. 2002; 95:2422-30.
    8. Wahlberg SS, et al. Cancer Res. 2002: 62:3485-92.
    9. Lanza G, et al. Mod Pathol. 2002; 15:741-9.


Clone IHC409
Source Mouse Monoclonal
Positive Control Colon, Colon Carcinoma
Dilution Range 1:100 - 1:400