GeneAb™

MMP-9

(In the pipeline)

Select Format:

Select Volume:

Price:

$145.00

Quantity:

Cat. No.

IHC009-100

Inquire

Description

Matrix Metalloproteinase-9 (MMP-9), also known as 92-kDa type IV collagenase or gelatinase B, is a member of a family of proteins involved in degradation of the extracellular matrix (ECM). MMP-9 is produced by neutrophils, macrophages, mast cells, and stromal cells, after activation in inflammatory tissues, and it has been reported that the protein may have a crucial role in angiogenesis and neovascularization. As degradation of collagen IV in the basement membrane and ECM promotes tumor progression, including invasion, metastasis, growth and angiogenesis, MMP-9 is involved in the development of several human malignancies. Overexpression of MMP-9 has been reported in a number of different cancers, including those of the breast and colon, as well as gastric and nasopharyngeal cancers.

Specifications

Clone IHC009
Source Mouse Monoclonal
Positive Control Breast Carcinoma, Placenta
Dilution Range 1:100 - 1:200

References

  1. Vandooren J, et al. Crit Rev Biochem Mol Biol. 2013; 48:222–72.
  2. Forsyth PA, et al. Br J Cancer. 1999; 79:1828-35.
  3. Heissig B, et al. Cell. 2002; 109:625–37.
  4. Morini M, et al. Int J Cancer. 2000; 87:336–42.
  5. Farina AR, et al. Cancers (Basel). 2014; 6:240–96.
  6. Zucker S, et al. Cancer. 1995; 76:700–8.
  7. Groblewska M, et al. Folia Histochem Cytobiol. 2012; 50:12–9.