GeneAb™

MMP-9

(In the pipeline)

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$145.00

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Cat. No.

IHC009-100

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Description

Matrix Metalloproteinase-9 (MMP-9), also known as 92-kDa type IV collagenase or gelatinase B, is a member of a family of proteins involved in degradation of the extracellular matrix (ECM). MMP-9 is produced by neutrophils, macrophages, mast cells, and stromal cells, after activation in inflammatory tissues, and it has been reported that the protein may have a crucial role in angiogenesis and neovascularization. As degradation of collagen IV in the basement membrane and ECM promotes tumor progression, including invasion, metastasis, growth and angiogenesis, MMP-9 is involved in the development of several human malignancies. Overexpression of MMP-9 has been reported in a number of different cancers, including those of the breast and colon, as well as gastric and nasopharyngeal cancers.
  • References
    1. Vandooren J, et al. Crit Rev Biochem Mol Biol. 2013; 48:222–72.
    2. Forsyth PA, et al. Br J Cancer. 1999; 79:1828-35.
    3. Heissig B, et al. Cell. 2002; 109:625–37.
    4. Morini M, et al. Int J Cancer. 2000; 87:336–42.
    5. Farina AR, et al. Cancers (Basel). 2014; 6:240–96.
    6. Zucker S, et al. Cancer. 1995; 76:700–8.
    7. Groblewska M, et al. Folia Histochem Cytobiol. 2012; 50:12–9.

Specifications

Clone IHC009
Source Mouse Monoclonal
Positive Control Breast Carcinoma, Placenta
Dilution Range 1:50-1:200

Literature