GeneAb™

MSH2

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$150.00

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Cat. No.

IHC410-100

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Description

MutS Homolog 2 (MSH2) is a protein involved in the mismatch-repair pathway. This protein is commonly associated with hereditary non-polyposis colorectal cancer, and mutations in this gene are correlated with the development of sporadic colorectal carcinoma. Expression levels of MSH2 are abnormally low in a high percentage of patients with microsatellite instability, as well as endometrial and ovarian cancers. Use of Anti-MSH2 is optimized when paired in an IHC panel with antibodies against MSH6, MLH1, and PMS2. Reports have shown Anti-MSH2 to be useful in the detection of the protein in a number of normal and neoplastic tissues, and for identifying a loss of MSH2 in tumors that are microsatellite-unstable.

Specifications

Clone IHC410
Source Mouse Monoclonal
Positive Control Colon Mucosa, Colon Carcinoma
Dilution Range 1:100 - 1:200

References

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  9. Thibodeau SN, et al. Cancer Res 1996; 56:4836-40.