GeneAb™

MSH6

(Coming soon)

Select Format:

Select Volume:

Price:

$0.00

Quantity:

Cat. No.

IHC006-100

Inquire

Description

MutS Homolog 6 (MSH6) is a protein involved in the mismatch-repair pathway. This protein is commonly associated with hereditary non-polyposis colorectal cancer, and mutations in this gene are correlated with the development of sporadic colorectal carcinoma. Studies have shown that mutations in MSH6, when co-indicated with mutations in MSH1 and MSH2, contribute to the development of sporadic colorectal carcinoma. Use of Anti-MSH6 is optimized when paired in an IHC panel with MSH2, MLH1, and PMS2.
  • References
    1. Lagerstedt Robinson K, et al. J Natl Cancer Inst. 2007; 99:291-9.
    2. Niessen RC, et al. Gut. 2006; 55:1781-8.
    3. Hansen TP, et al. Appl Immunohistochem Mol Morphol. 2006; 14:115-21.
    4. Lawes DA, et al. Br J Cancer. 2005; 93:472-7.
    5. Stormorken AT, et al. J Clin Oncol. 2005; 23:4705-12.
    6. Rigau V, et al. Arch Pathol Lab Med. 2003; 127:694-700.
    7. Renkonen E, et al. J Clin Oncol. 2003; 21:3629-37.

Specifications

Clone IHC006
Source Mouse Monoclonal
Positive Control Colon, Colon Carcinoma
Dilution Range 1:50-1:200

Literature