![GeneAb™ MSH6 [IHC026] on colon tissue with intact (A) and loss of MSH6 expression (Negative, B)](/images/product/original/MSH6-IHC026-Colon-Cancer-pos-neg-3.jpg) 
                      
                          
                          GeneAb™ MSH6 [IHC026] on colon tissue with intact (A) and loss of MSH6 expression (Negative, B)
MutS Homolog 6 (MSH6) is a protein involved in the mismatch repair pathway. This protein is commonly associated with hereditary non-polyposis colorectal cancer, and mutations in this gene are correlated with the development of sporadic colorectal carcinoma. Studies have shown that mutations in MSH6, when co-indicated with mutations in MSH1 and MSH2, contribute to the development of sporadic colorectal carcinoma. Use of Anti-MSH2 is optimized when paired with MSH6, MLH1, and PMS2 in an IHC panel.
                     CLONE:
                     IHC026
                     ISOTYPE:
                     IgG, kappa
                     HOST SPECIES:
                     Rabbit
                     CLONALITY:
                     Monoclonal
                     POSITIVE CONTROL:
                     Colon Cancer
                     DILUTION RANGE:
                     
                     INTENDED USE/REG. STATUS:
                      RUO
                      
                      ADDITIONAL INFORMATION:
                      NordiQC Rating: Optimal 
(Assessment Run 61 2021)
                      
                  
 
					 
						 
						 
					
