GeneAb™

MSH6

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$130.00

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Cat. No.

IHC006-100

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Description

MutS Homolog 6 (MSH6) is a protein involved in the mismatch-repair pathway. This protein is commonly associated with hereditary non-polyposis colorectal cancer, and mutations in this gene are correlated with the development of sporadic colorectal carcinoma. Studies have shown that mutations in MSH6, when co-indicated with mutations in MSH1 and MSH2, contribute to the development of sporadic colorectal carcinoma. Use of Anti-MSH6 is optimized when paired in an IHC panel with MSH2, MLH1, and PMS2.

Specifications

Clone IHC006
Source Mouse Monoclonal
Positive Control Colon, Colon Carcinoma
Dilution Range 1:100 - 1:200

References

  1. Lagerstedt Robinson K, et al. J Natl Cancer Inst. 2007; 99:291-9.
  2. Niessen RC, et al. Gut. 2006; 55:1781-8.
  3. Hansen TP, et al. Appl Immunohistochem Mol Morphol. 2006; 14:115-21.
  4. Lawes DA, et al. Br J Cancer. 2005; 93:472-7.
  5. Stormorken AT, et al. J Clin Oncol. 2005; 23:4705-12.
  6. Rigau V, et al. Arch Pathol Lab Med. 2003; 127:694-700.
  7. Renkonen E, et al. J Clin Oncol. 2003; 21:3629-37.