GeneAb™

MUC1

Select Format:

Select Volume:

Price:

$130.00

Quantity:

Cat. No.

IHC623-100

Inquire

Description

Mucin 1 (MUC1) is a membrane-bound glycoprotein involved in a number of protective and cell-signaling functions, including cell-cell adhesion, proliferation, motility, invasion, and survival. Overexpression of MUC1 is clinically indicated in breast carcinomas, papillary thyroid carcinomas, and thymic carcinomas, and reports have named MUC1 as a useful marker for differentiating thymic carcinoma from type B3 thymoma. The expression of MUC1 is correlated with the grade of malignancy in thymic epithelial tumors, and loss of MUC1 expression has been associated with reactive gastropathy. MUC1 is not expressed in normal human epidermis, but has been detected in the epidermis of psoriatic plaques of biopsies from patients diagnosed with psoriasis vulgaris.

Specifications

Clone IHC623
Source Mouse Monoclonal
Positive Control Breast, Colon, Associated Adenocarcinomas
Dilution Range 1:100 - 1:200

References

  1. Arciniegas E, et al. Histol Histopathol. 2015; 30:453-63.
  2. Mino-Kenudson M, et al. Arch Pathol Lab Med. 2007; 131:86-90.
  3. Zhan XX, et al. Endocr Pathol. 2015; 26:21-6.
  4. Renaud F, et al. Thyroid. 2014; 24:1375-84.
  5. Kaira K, et al. Virchows Arch. 2011; 458:615-20.
  6. Hu XF, et al. Expert Rev Anticancer Ther. 2006; 6:1261-71
  7. Leroy X, et al. Ann Pathol. 2007; 26:257-66.
  8. Li Y, Cozzi PJ, Curr Cancer Drug Targets. 2007; 7:259-71.
  9. O’Connell FP, et al. Arch Pathol Lab Med. 2005; 129:338-47