GeneAb™

Macrophage

(In the pipeline)

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$115.00

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Cat. No.

IHC618-100

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Description

Macrophages are a type of white blood cell present in essentially all tissues, functioning in host defense via phagocytosis and pinocytosis. Macrophages digest and present antigens to T- and B-lymphocytes, and also work to secrete complement components, coagulation factors, many regulatory molecules including interferon and interleukin 1, as well as some prostaglandins and leukotrienes. Macrophages are associated with a large proportion of malignant tumors, and have been reported as a promising target for cancer therapies due to their angiogenesis-promoting and trophic roles. Anti-Macrophage, also known as HAM-56, detects tingible body macrophages found in the germinal centers of lymph nodes, as well as a subpopulation of endothelial cells, namely those of the capillaries and smaller blood vessels. Anti-Macrophage also reacts with interdigitating macrophages of lymph nodes and tissue macrophages, Kupffer cells of the liver, and alveolar macrophages of the lung.

Specifications

Clone IHC618
Source Mouse Monoclonal
Positive Control Tonsil
Dilution Range 1:100 - 1:200

References

  1. Ovchinnikov DA. Genesis. 2008; 46:447-62.
  2. Gown AM, et al. Am J Pathol. 1986; 125:191-207.
  3. Bosman C, et al. J Pediatr Hematol Oncol. 1999; 21:31-7.
  4. Alpers CE, et al. Am J Pathol. 1989; 92:662-5.
  5. Soini Y, et al. Pathol Res Pract. 1990; 186:759-67.