GeneAb™

Macrophage

(In the pipeline)

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Cat. No.

IHC618-100

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Description

Macrophages are a type of white blood cell present in essentially all tissues, functioning in host defense via phagocytosis and pinocytosis. Macrophages digest and present antigens to T- and B-lymphocytes, and also work to secrete complement components, coagulation factors, many regulatory molecules including interferon and interleukin 1, as well as some prostaglandins and leukotrienes. Macrophages are associated with a large proportion of malignant tumors, and have been reported as a promising target for cancer therapies due to their angiogenesis-promoting and trophic roles. Anti-Macrophage, also known as HAM-56, detects tingible body macrophages found in the germinal centers of lymph nodes, as well as a subpopulation of endothelial cells, namely those of the capillaries and smaller blood vessels. Anti-Macrophage also reacts with interdigitating macrophages of lymph nodes and tissue macrophages, Kupffer cells of the liver, and alveolar macrophages of the lung.
  • References
    1. Ovchinnikov DA. Genesis. 2008; 46:447-62.
    2. Gown AM, et al. Am J Pathol. 1986; 125:191-207.
    3. Bosman C, et al. J Pediatr Hematol Oncol. 1999; 21:31-7.
    4. Alpers CE, et al. Am J Pathol. 1989; 92:662-5.
    5. Soini Y, et al. Pathol Res Pract. 1990; 186:759-67.

Specifications

Clone IHC618
Source Mouse Monoclonal
Positive Control Tonsil
Dilution Range 1:50-1:200

Literature