Macrophage (In the pipeline)
Macrophages are a type of white blood cell present in essentially all tissues, functioning in host defense via phagocytosis and pinocytosis. Macrophages digest and present antigens to T- and B-lymphocytes, and also work to secrete complement components, coagulation factors, many regulatory molecules including interferon and interleukin 1, as well as some prostaglandins and leukotrienes. Macrophages are associated with a large proportion of malignant tumors, and have been reported as a promising target for cancer therapies due to their angiogenesis-promoting and trophic roles. Anti-Macrophage, also known as HAM-56, detects tingible body macrophages found in the germinal centers of lymph nodes, as well as a subpopulation of endothelial cells, namely those of the capillaries and smaller blood vessels. Anti-Macrophage also reacts with interdigitating macrophages of lymph nodes and tissue macrophages, Kupffer cells of the liver, and alveolar macrophages of the lung.
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