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N-cadherin, also known as Cadherin-2 (CDH2) or Neural Cadherin (NCAD), is a transmembrane cell adhesion molecule that was originally detected in nervous tissue. It plays an important role in embryogenesis, being involved in gastrulation and neural crest development. N-cadherin is found is cancer cells and allows for transendothelial migration, which is a critical process in the metastasis of cancer. Overexpression and disorderly arrangement of N-cadherin has been noted in dilated cardiomyopathy. It has been suggested that, when considered in adjunct with the status of a number of additional cell-cell adhesion molecules, missense mutations in N-cadherin may be a potential indicator of obsessive-compulsive disorder and Tourette disorder.
  • References
    1. Walsh FS, et al. J Neurochem. 1990; 55:805-12.
    2. Reid RA, et al. Nucleic Acids Res. 1990; 18:5896.
    3. Ramis-Conde, I, et al. Phys Biol. 2009; 6:016008.
    4. Moya PR, et al. Eur J Human Genet. 2013; 21:850-4.
    5. Tsipis A, et al. Pathol Res Pract. 2010; 206:625-30.
    6. Derycke LD, et al. Int J Dev Biol. 2004; 48:463-76.


Clone IHC636
Source Mouse Monoclonal
Positive Control Breast
Dilution Range 1:50-1:200