GeneAb™

Oct-4

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$190.00

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Cat. No.

IHC643-100

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Description

Octamer-binding transcription factor 4 (Oct-4), also known as POU5F1 (POU domain, class 5, transcription factor 1), is a member of the POU homeodomain family of transcription factors and is involved in the maintenance and regulation of pluripotency in embryonic stem and germ cells. Anti-Oct-4 is highly useful and sensitive for seminomas, germinoma, dysgerminoma, embryonal carcinoma, and gonadoblastoma. Oct-4 may be associated with tumorigenesis, and can have an effect on some aspects of tumor behavior, including tumor recurrence or resistance to therapies.

Specifications

Clone IHC643
Source Mouse Monoclonal
Positive Control Seminoma
Dilution Range 1:100 - 1:200

References

  1. Baker PM, et al. Int J Gynecol Pathol. 2005; 24:39-55.
  2. Biermann K, et al. Histopathology. 2006; 49:290-7.
  3. Cheng CJ, et al. J Biomed Sci. 2007; 14:797-807.
  4. Cools M, et al. J Clin Endocrinol Metab. 2006; 91:2404-13.
  5. Niwa H, et al. Nat Genet. 2000; 24:372-6.
  6. Biermann K, et al. Histopathology. 2006; 49:290-7.
  7. Cheng L, et al. J Pathol. 2007; 211:1-9.
  8. Linn DE, et al. Genes Cancer. 2010; 1:908-16.