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Octamer-binding transcription factor 4 (Oct-4), also known as POU5F1 (POU domain, class 5, transcription factor 1), is a member of the POU homeodomain family of transcription factors and is involved in the maintenance and regulation of pluripotency in embryonic stem and germ cells. Anti-Oct-4 is highly useful and sensitive for seminomas, germinoma, dysgerminoma, embryonal carcinoma, and gonadoblastoma. Oct-4 may be associated with tumorigenesis, and can have an effect on some aspects of tumor behavior, including tumor recurrence or resistance to therapies.
  • References
    1. Baker PM, et al. Int J Gynecol Pathol. 2005; 24:39-55.
    2. Biermann K, et al. Histopathology. 2006; 49:290-7.
    3. Cheng CJ, et al. J Biomed Sci. 2007; 14:797-807.
    4. Cools M, et al. J Clin Endocrinol Metab. 2006; 91:2404-13.
    5. Niwa H, et al. Nat Genet. 2000; 24:372-6.
    6. Biermann K, et al. Histopathology. 2006; 49:290-7.
    7. Cheng L, et al. J Pathol. 2007; 211:1-9.
    8. Linn DE, et al. Genes Cancer. 2010; 1:908-16.


Clone IHC643
Source Mouse Monoclonal
Positive Control Seminoma
Dilution Range 1:50-1:200