PGP 9.5 (In the pipeline)
Protein Gene Product 9.5 (PGP 9.5), also known as Ubiquitin Carboxyl-terminal Hydrolase-1 (UCHL-1), is a protein expressed in neurons and neuroendocrine cells, as well as in distal renal tubular epithelium, spermatogonia, Leydig cells, oocytes, melanocytes, prostatic secretory epithelium, ejaculatory duct cells, epididymis, mammary epithelial cells, Merkel cells, and dermal fibroblasts. PGP 9.5 is an immunohistochemical marker for cellular neurothekeoma, a benign lesion that is typically confined to the skin and superficial dermis. Anti-PGP 9.5 is also used to stain mesenchymal neoplasms, and tumors of neuroendocrine and neuroectodermal origin.
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