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Special AT-rich sequence-Binding protein 2 (SATB2), also known as DNA-binding protein SATB2, is a protein associated with the nuclear matrix that is involved in transcriptional regulation and chromatin remodeling. SATB2 has been identified as a potentially useful marker for neuroendocrine neoplasms or carcinomas of the colon and rectum, as well as for detecting osteoblastic differentiation in benign and malignant mesenchymal tumors. When used in combination with Cytokeratin 20 and Cadherin 17, Anti-SATB2 is able to help identify the large majority of colorectal carcinomas, including those that are poorly differentiated. Anti-SATB2 is useful for identifying colorectal carcinomas when working on a tumor of unknown primary origin, as upper gastrointestinal carcinomas, pancreatic ductal carcinomas, ovarian carcinomas, lung adenocarcinomas, and adenocarcinomas from other origin are all typically negative for SATB2.
  • References
    1. Kikuno R, et al. DNA Res. 1999; 6:197–205.
    2. Rosenfeld JA, et al. PLoS One. 2009; 4:e6568.
    3. Magnusson K, et al. Am J Surg Pathol. 2011; 35:937-48.
    4. Lin F, et al. Arch Pathol Lab Med. 2014; 138:1015-26.
    5. Li Z, et al. Mod Pathol. 2013; 26:164A.
    6. Conner JR, et al. Histopathology. 2013; 63:182-93.
    7. Dragomir A, et al. Am J Clin Pathol. 2014; 141:630-8.


Clone IHC660
Source Mouse Monoclonal
Positive Control Colon Adenocarcinoma, Colon
Dilution Range 1:50-1:200