GeneAb™

SOX10

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$165.00

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Cat. No.

IHC010-100

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Description

SRY (Sex Determining Region Y)-Box 10 (SOX-10), also known as transcription factor SOX-10, is a nuclear transcription factor that acts in regulation of embryonic development and in the specification and differentiation of cells of melanocytic lineage. SOX-10 is diffusely expressed in neurofibromas and schwannomas, and mutations in the SOX-10 gene are linked to Waardenburg-Shah and Waardenburg-Hirschsprung disease. Anti-SOX-10 has been shown to be sensitive for conventional, spindled, and desmoplastic melanoma, and has been used to detect metastatic melanoma and nodal capsular nevus in sentinel lymph nodes.

Specifications

Clone IHC010
Source Mouse Monoclonal
Positive Control Melanoma, Skin Melanocytes
Dilution Range 1:100 - 1:200

References

  1. Pingault V, et al. Nat Genet. 1998; 18:171-3.
  2. Bondurand N, et al. Hum Mol Genet. 2000; 8:1785-9.
  3. Kelsch RN. BioEssays. 2006; 28:788.
  4. Nonaka D, et al. Am J Surg Pathol. 2008; 32:1291-8.
  5. Chorny JA, et al. Am J Dermatopathol. 2002; 24:309-12.
  6. Robson A, et al. Histopathology. 2001; 38:135-40.
  7. Longacre T, et al. Am J Surg Pathol. 1996; 20:1489-500.
  8. Ramos-Herberth FI, et al. J Cutan Pathol. 2010; 37:944–52.