GeneAb™

SOX10

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$100.00

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Cat. No.

IHC010-100

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Description

SRY (Sex Determining Region Y)-Box 10 (SOX-10), also known as transcription factor SOX-10, is a nuclear transcription factor that acts in regulation of embryonic development and in the specification and differentiation of cells of melanocytic lineage. SOX-10 is diffusely expressed in neurofibromas and schwannomas, and mutations in the SOX-10 gene are linked to Waardenburg-Shah and Waardenburg-Hirschsprung disease. Anti-SOX-10 has been shown to be sensitive for conventional, spindled, and desmoplastic melanoma, and has been used to detect metastatic melanoma and nodal capsular nevus in sentinel lymph nodes.
  • References
    1. Pingault V, et al. Nat Genet. 1998; 18:171-3.
    2. Bondurand N, et al. Hum Mol Genet. 2000; 8:1785-9.
    3. Kelsch RN. BioEssays. 2006; 28:788.
    4. Nonaka D, et al. Am J Surg Pathol. 2008; 32:1291-8.
    5. Chorny JA, et al. Am J Dermatopathol. 2002; 24:309-12.
    6. Robson A, et al. Histopathology. 2001; 38:135-40.
    7. Longacre T, et al. Am J Surg Pathol. 1996; 20:1489-500.
    8. Ramos-Herberth FI, et al. J Cutan Pathol. 2010; 37:944–52.

Specifications

Clone IHC010
Source Mouse Monoclonal
Positive Control Melanoma, Skin Melanocytes
Dilution Range 1:50-1:200

Literature