GeneAb™

SOX 2

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$70.00

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Cat. No.

IHC665-100

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Description

SOX 2, also known as SRY (sex determining region Y)-box 2, is a transcription factor that acts to regulate pluripotency of undifferentiated embryonic stem cells, and to regulate gene expression in the stomach. This diagnostic grade SOX 2 IVD antibody is used to detect melanoma, testicular germ cell tumor, cervical carcinoma, lung cancer, breast cancer with basal cell phenotype, and teratoma of the central nervous system. SOX 2 has been reported as a predictor of poor outcome in stage I lung adenocarcinomas. Anti-SOX 2 is also used to recognize squamous cell carcinomas of the lung and gastrointestinal tract, and may be useful for detecting embryonal carcinoma.
  • References
    1. Rizzino A, et al. Wiley Interdiscip Rev Syst Biol Med. 2009; 1:228-36.
    2. Laga AC, et al. Am J Pathol. 2010; 176:903-13.
    3. Ji J, et al. Hum Pathol. 2010; 41:1438-47.
    4. Rodriguez-Pinilla SM, et al. Mod Pathol. 2007; 20:474-81.
    5. Long KB, et al. Hum Pathol. 2009; 40:1768-73.
    6. Sholl LM, et al. Appl Immunohistochem Mol Morphol. 2010; 18:55–61.
    7. Tsuta K, et al. J Thorac Oncol. 2011; 6:1190-9.
    8. Gopalan A, et al. Mod Pathol. 2009; 22:1066-74.

Specifications

Clone IHC665
Source Mouse Monoclonal
Positive Control Lung Squamous Carcinoma
Dilution Range 1:100 - 1:400

Literature