GeneAb™

SOX 2

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$120.00

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Cat. No.

IHC665-100

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Description

SOX 2, also known as SRY (sex determining region Y)-box 2, is a transcription factor that acts to regulate pluripotency of undifferentiated embryonic stem cells, and to regulate gene expression in the stomach. This diagnostic grade SOX 2 IVD antibody is used to detect melanoma, testicular germ cell tumor, cervical carcinoma, lung cancer, breast cancer with basal cell phenotype, and teratoma of the central nervous system. SOX 2 has been reported as a predictor of poor outcome in stage I lung adenocarcinomas. Anti-SOX 2 is also used to recognize squamous cell carcinomas of the lung and gastrointestinal tract, and may be useful for detecting embryonal carcinoma.

Specifications

Clone IHC665
Source Mouse Monoclonal
Positive Control Lung Squamous Carcinoma
Dilution Range 1:100 - 1:200

References

  1. Rizzino A, et al. Wiley Interdiscip Rev Syst Biol Med. 2009; 1:228-36.
  2. Laga AC, et al. Am J Pathol. 2010; 176:903-13.
  3. Ji J, et al. Hum Pathol. 2010; 41:1438-47.
  4. Rodriguez-Pinilla SM, et al. Mod Pathol. 2007; 20:474-81.
  5. Long KB, et al. Hum Pathol. 2009; 40:1768-73.
  6. Sholl LM, et al. Appl Immunohistochem Mol Morphol. 2010; 18:55–61.
  7. Tsuta K, et al. J Thorac Oncol. 2011; 6:1190-9.
  8. Gopalan A, et al. Mod Pathol. 2009; 22:1066-74.